Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis
ABSTRACT Tight coordination of inner and #Stirrups outer membrane biosynthesis is very important in Gram-negative bacteria.Biosynthesis of the lipid A moiety of lipopolysaccharide, which comprises the outer leaflet of the outer membrane has garnered interest for Gram-negative antibacterial discovery.In particular, several potent inhibitors of LpxC