INTERPLAY OF KLEBSIELLA PNEUMONIAE FABZ AND LPXC MUTATIONS LEADS TO LPXC INHIBITOR-DEPENDENT GROWTH RESULTING FROM LOSS OF MEMBRANE HOMEOSTASIS

Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis

ABSTRACT Tight coordination of inner and #Stirrups outer membrane biosynthesis is very important in Gram-negative bacteria.Biosynthesis of the lipid A moiety of lipopolysaccharide, which comprises the outer leaflet of the outer membrane has garnered interest for Gram-negative antibacterial discovery.In particular, several potent inhibitors of LpxC

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Instances of Formalistic "Subject" in Persian Short Stories

In the poetics of formalism, the two issues of "story" and "plot" have been redefined depending on the ultimate goal of this theory that is defamiliarization.Based on the new definitions, "story" that was believed to be the temporal chain of events, is presently known as the raw material of the narrative called fibula.Similarly, "plot", in oppositi

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